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Alternative splicing differences between humans and chimpanzees

A new paper will come out on Genes and Development on Nov 15:

Calarco, JA.*, Xing, Y.*, Caceres, M.*, Calarco, JP., Xiao, X., Pan, Q., Lee, C.,, Preuss, T. and Blencowe, B. (2007) Global analysis of alternative splicing differences between humans and chimpanzees. Genes and Development.

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Comments (1)

Rileen:

As a Bioinformatics Ph.D student working on Alternative Splicing, I've been waiting for something like this. Glad to know that the wait is going to be over next month.

A question - has any such study already been published for Humans and Mice? As far as I know, there are several Bioinformatics papers which say that the conservation of alternative splicing events between Humans and Mice is pretty low, in the 10%-20% range. On the other hand, Michael Tress of the ENCODE consortium said (at the AS-SIG in the ISMB/ECCB 2007 conference) that they found much higher conservation, over 50%.

Last but not the least, I want to thank you for your previous blog on Alternative Splicing, which has been very useful for me.

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